Sunday, May 27, 2012

B-cell lymphoma genetic links

Genetics of lymphomas - translocations cause overexpression of the following genes which cause the disease:
  • myc - Burkitts + B & T-cell lymphomas
  • bcl2 = follicular B-cell lymphoma
  • bcl3 = chronic B-cell lymphoma
  • bcl6 = diffuse  B-cell lymphoma
  • any other genes = acute T-cell lymphoma
So you can use this mirror image to remember the bcl genes:

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